Towards component-based validation of GATE: aspects of the coincidence processor.

Published in Physica Medica

GATE is public domain software widely used for Monte Carlo simulation in emission tomography. Validations of GATE have primarily been performed on a whole-system basis, leaving the possibility that errors in one sub-system may be offset by errors in others. We assess the accuracy of the GATE PET coincidence generation sub-system in isolation, focus...

Acanthosis nigricans associated with acute myeloid leukaemia.

Published in European Journal of Internal Medicine

Ancient schwannoma masquerading as a thyroid mass.

Published in European Journal of Surgical Oncology

Schwannomas are benign, encapsulated nerve sheath cell neoplasms. Cervical sympathetic chain (CSC) schwannomas are rare, with less than 50 cited cases in the literature. CSC schwannomas may mimic a number of parapharyngeal masses. We report a rare variant, "ancient" schwannoma, which presented cytologically and radiologically as a thyroid mass. Thi...

Routine screening for CYP2C19 polymorphisms for patients being treated with clopidogrel is not recommended.

Published in Hawai i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health

Recent efforts directed at potential litigation in Hawai i have resulted in a renewed interest for genetic screening for cytochrome P450 2C19 (CYP2C19) polymorphisms in patients treated with clopidogrel. Clopidogrel is an antiplatelet agent, frequently used in combination with aspirin, for the prevention of thrombotic complications with acute coron...

Developments in component-based normalization for 3D PET.

Published in Physics in Medicine and Biology

Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode...

Comparison of two-dimensional and three-dimensional iterative watershed segmentation methods in hepatic tumor volumetric...

Published in Medical Physics

In this work the authors compare the accuracy of two-dimensional (2D) and three-dimensional (3D) implementations of a computer-aided image segmentation method to that of physician observers (using manual outlining) for volume measurements of liver tumors visualized with diagnostic contrast-enhanced and PET/CT-based non-contrast-enhanced (PET-CT) CT...

Prevention of systolic anterior motion after mitral valve repair with an anterior leaflet valvuloplasty.

Published in The Journal of heart valve disease

Quantitative Accuracy of Penalized-Likelihood Reconstruction for ROI Activity Estimation.

Published in IEEE Transactions on Nuclear Science

Estimation of the tracer uptake in a region of interest (ROI) is an important task in emission tomography. ROI quantification is essential for measuring clinical factors such as tumor activity, growth rate, and the efficacy of therapeutic interventions. Accuracy of ROI quantification is significantly affected by image reconstruction algorithms. In ...

NEC: some coincidences are more equivalent than others.

Published in Journal of Nuclear Medicine

Optimal whole-body PET scanner configurations for different volumes of LSO scintillator: a simulation study.

Published in Physics in Medicine and Biology

The axial field of view (AFOV) of the current generation of clinical whole-body PET scanners range from 15-22 cm, which limits sensitivity and renders applications such as whole-body dynamic imaging or imaging of very low activities in whole-body cellular tracking studies, almost impossible. Generally, extending the AFOV significantly increases the...