Evaluation of penalty design in penalized maximum-likelihood image reconstruction for lesion detection.
Published in Journal of medical imaging (Bellingham, Wash.)
Detecting cancerous lesions is a major clinical application in emission tomography. Previously, we developed a method to design a shift-variant quadratic penalty function in penalized maximum-likelihood (PML) image reconstruction to improve the lesion detectability. We used a multiview channelized Hotelling observer (mvCHO) to assess the lesion det...
